منابع مشابه
Hormonal control of immunoreactive somatomedin production by cultured human fibroblasts.
Human growth hormone (hGH) is known to be a potent stimulator of somatomedin secretion in vivo. The induction of somatomedin by growth hormone has been difficult to study in vitro, however, because no organ containing a high concentration of somatomedin has been identified. Because fetal mouse explants have been shown to produce somatomedin in vitro, we have undertaken studies to determine whet...
متن کاملThe somatomedin hypothesis: 2001.
Since the original somatomedin hypothesis was conceived, a number of important discoveries have allowed investigators to modify the concept. Originally somatic growth was thought to be controlled by pituitary GH and mediated by circulating insulin-like growth factor-I (IGF-I, somatomedin C) expressed exclusively by the liver. With the discovery that IGF-I is produced by most, if not all, tissue...
متن کاملEffect of low molecular weight human serum factors and human somatomedin peptides on human lymphocyte cultures.
Using PH]thymidine incorporation into DNA of human lymphocytes in culture, we have shown that human serum contains an ultrafiltrable factor(s) that sensitizes the activation of lymphocytes by phytohaemagglutinin. This (these) factor(s) can replace either human serum or foetal calf serum in the culture. In addition, it permits the expression, and therefore the assay, of human somatomedin A pepti...
متن کاملDifferentiation of human embryonic stem cells into neurons
Human embryonic stem (ES) cells are undifferentiated pluripotent cells derived from the inner cell mass of blastocyst stage embryos. These unique cell lines have the potential to form virtually any cell type in the body and can be propagated in vitro indefinitely in an undifferentiated state. These cells are capable of forming embryoid bodies (EB) that contain cells from all three embryonic lin...
متن کاملDietary constituents and somatomedin activity.
Serum somatomedin activity of rats was measured under several dietary conditions by 35S incorporation into chick embryo pelvic rudiment. The mean (+/- SD) serum somatomedin activity (U/ml) was reduced following 3 days of fasting (0.41 +/- 0.12) and increased to prefasting levels in animals fed a balanced diet (0.95 +/- 0.11) for 2 days. The increase in mean somatomedin activity following 2 day...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1981
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.78.5.3175